Bioavailability of Intranasal Dexmedetomidine (INDEX)

Turku University Hospital (TYKS)

Status and phase

Completed

Phase 4

Conditions

Arthritis of Hip

Arthritis Knee

Anesthesia

Pharmacokinetics

Treatments

Device: Dexmedetomidine

Study type

Interventional

Funder types

Other

Identifiers

NCT05065775

INDEX

Details and patient eligibility

About

Aim of this study is to characterize the pharmacokinetics of dexmedetomidine in supine, anesthetized adult patients after intranasal dosing.

Full description

To date, intranasal dexmedetomidine pharmacokinetics have not been studied before on anesthetized adult patients in supine position. As use of intranasal dexmedetomidine is growing, it is crucial to enhance knowledge of its pharmacokinetics.

Open, exploratory study design will be used. Study population will consist of patients coming to elective unilateral hip or knee arthroplasty under general anesthesia in Turku University Hospital, Salo unit. Thirty patients compatible with the inclusion and exclusion criteria will be entered into the study after receiving informed consent. Plasma concentrations of dexmedetomidine and other significant data will be collected prospectively.

Intranasal dexmedetomidine 100 ug will be administered shortly after induction of general anesthesia using a mucosal atomization (LMA MAD Nasal™) device, according to normal local protocol. Second cannula will be placed after patient is anesthetized, in order to obtain blood samples. Venous blood samples will be obtained immediately prior to administration of dexmedetomidine (baseline) and thereafter at 5, 15, 45 min and 1, 4 h into EDTA tubes for determination of dexmedetomidine, and possibly adrenaline and noradrenaline plasma concentrations.

Vital signs (heart rate, blood pressure and peripheral oxygen saturation) will be followed during the operation, as well as in the post anesthesia care unit according to the local protocol. Before patients will be admitted to the ward, they are expected to be appropriately arousable and have vital signs in normal limits.

Enrollment

30 patients

Sex

All

Ages

35 to 85 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

The patient is scheduled for elective unilateral total knee arthroplasty or hip arthroplasty under general anesthesia
Fluent skills in finnish language (to understand the given information and to be able to give informed consent and communicate with the study personnel)
Age between 35 and 80 years
Weight between 50 and 100 kg
ASA (American Society of Anesthesiologists) status 1-3
Written informed consent from the patient

Exclusion criteria

A previous history of intolerance to the study drug or related compounds and additives
Disease or condition affecting patient's ability to give written informed consent
Existing or recent significant disease possible affecting absorption, distribution, metabolism, excretion or response to the study drug
History of cardiac disease (valvular insufficiency, severe left ventricular dysfunction) or abnormal ECG rhythm (bradycardia < 50/min, 2nd or 3rd degree atrio-ventricular block, pacemaker)
Chronic opioid use or use of other analgesic adjuvants such as pregabalin, gabapentin, amitriptyline or duloxetine
Participation in any other study concomitantly or within one month prior to the entry into this study
Clinically significant abnormal findings in physical examination or laboratory screening
Use of drugs or natural products known to cause enzyme induction or inhibition
Pregnancy or breastfeeding
Spinal anesthesia
Preoperative systolic blood pressure <110 mmHg