Bioavailability of Potassium From Potatoes and Potassium Gluconate

Purdue University

Status: Completed

Conditions: Potassium Bioavailability; Blood Pressure

Treatments: Dietary Supplement: Low dose potato; Dietary Supplement: High dose potato; Dietary Supplement: Medium dose potassium gluconate; Dietary Supplement: High dose French fries; Dietary Supplement: Medium dose potato; Dietary Supplement: Basal diet control; Dietary Supplement: High dose potassium gluconate; Dietary Supplement: Low dose potassium gluconate; Dietary Supplement: Placebo control

Study type: Interventional

Funder types: Other

Identifiers

NCT01881295

1301013174

Details and patient eligibility

About

This study is designed to compare the effect of sources of potassium on uptake and the effect of potassium on blood pressure.

Full description

The study will compare uptake of potassium from three different doses and sources; supplements (720, 1440 and 2160 mg) potatoes (720, 1440 and 2160 mg) or French fries (2160 mg).

During 9 phases, participants will consume a controlled diet with the supplements, potato or french fries (every other week for 5 days). On the 4th day, blood and urine samples will be taken to monitor potassium uptake and excretion. Measures of blood pressure will be analyzed at defined time points throughout the intervention.

Enrollment: 45 patients

Sex: All

Ages: 20 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Able to adhere to the visit schedule, protocol requirements and available to complete the study
• Normotensive men and women
• Aged 20-60 years
• BMI of 15-35

Exclusion criteria

• Medication to treat hypertension or hypotension
• Medication known to affect electrolyte metabolism or contain high levels of potassium or sodium
• smoke cigarettes or use illegal drugs
• Hypertension or hypotension
• Diseases known to affect potassium metabolism
• Pregnant
• Allergic to nuts

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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45 participants in 9 patient groups, including a placebo group

Placebo control

Placebo Comparator group

Description:

Subjects will consume tablets containing no potassium in addition to a basal diet containing 2336 mg potassium

Treatment:

Dietary Supplement: Placebo control

Low dose potassium gluconate

Experimental group

Description:

Subjects will consume 720 mg potassium in the form of potassium gluconate tablets daily in addition to a basal diet containing 2336 mg potassium

Treatment:

Dietary Supplement: Low dose potassium gluconate

Medium dose potassium gluconate

Experimental group

Description:

Subjects will consume 1440 mg potassium in the form of potassium gluconate tablets daily in addition to a basal diet containing 2336 mg potassium

Treatment:

Dietary Supplement: Medium dose potassium gluconate

High dose potassium gluconate

Experimental group

Description:

Subjects will consume 2160 mg potassium in the form of potassium gluconate tablets daily in addition to a basal diet containing 2336 mg potassium

Treatment:

Dietary Supplement: High dose potassium gluconate

Low dose potato

Experimental group

Description:

Subjects will consume 720 mg potassium in the form of potato daily in addition to a basal diet containing 2336 mg potassium

Treatment:

Dietary Supplement: Low dose potato

Medium dose potato

Experimental group

Description:

Subjects will consume 1440 mg potassium in the form of potato daily in addition to a basal diet containing 2336 mg potassium

Treatment:

Dietary Supplement: Medium dose potato

High dose potato

Experimental group

Description:

Subjects will consume 2160 mg potassium in the form of potato daily in addition to a basal diet containing 2336 mg potassium

Treatment:

Dietary Supplement: High dose potato

High dose French fries

Experimental group

Description:

Subjects will consume 2160 mg potassium in the form of french fries daily in addition to a basal diet containing 2336 mg potassium

Treatment:

Dietary Supplement: High dose French fries

Basal diet control

Experimental group

Description:

Subjects will consume a basal diet containing 2336 mg potassium daily

Treatment:

Dietary Supplement: Basal diet control