Bioavailability of Resveratrol From Vineatrol30 Extract Incorporated Into Micelles

University of Hohenheim

Status and phase: Completed; Early Phase 1

Conditions: Safety After Oral Intake; Pharmacokinetics After Oral Intake

Treatments: Dietary Supplement: Vineatrol 30 native powder; Dietary Supplement: Vineatrol 30 micelles

Study type: Interventional

Funder types: Other

Identifiers

NCT02944097

HS-VM-2015

Details and patient eligibility

About

To enhance the oral bioavailability of the antioxidants trans-resveratrol and trans-ε-viniferin from Vineatrol30 grapevine-shoot extract, the native powder was incorporated into micelles. A single dose, single blind, two arms crossover trial was conducted. Plasma and urine samples were collected at intervals up to 24 h after oral intake of native or micellar Vineatrol30 (500 mg), and resveratrol content was quantified and compared between formulations. Tolerability of the dose was also controlled by safety parameters in plasma.

Enrollment: 12 patients

Sex: All

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Healthy Volunteers with blood chemistry values within normal ranges

Age: 18-35 years

BMI: 19-25 kg/m2

Exclusion criteria

Pregnancy or lactation

Alcohol and/or drug abuse

Use of dietary supplements or any medications, except contraceptives

Any known malignant, metabolic and endocrine diseases

Previous cardiac infarction

Dementia

Participation in a clinical trial within the past 6 weeks prior to recruitment

Smoking

Physical activity of more than 5 h/wk

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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12 participants in 2 patient groups

Vineatrol30 native powder

Experimental group

Description:

500 mg Vineatrol30 containing 30 mg trans-resveratrol and 75.2 mg trans-epsilon-viniferin

Treatment:

Dietary Supplement: Vineatrol 30 native powder

Vineatrol30 micelles

Experimental group

Description:

500 mg Vineatrol30 micelles containing 30 mg trans-resveratrol and 75.2 mg trans-epsilon-viniferin

Treatment:

Dietary Supplement: Vineatrol 30 micelles