Biobank and Register of Patients With Agresive Tumors for Translational and Analytical Research (REGATA)

N.N. Petrov National Medical Research Center of Oncology

Status: Enrolling

Conditions: Melanoma; Soft Tissue Sarcoma; Kidney Cancer; Malignant Solid Tumors; Prostate Cancer; Primary Brain Tumor; Colorectal Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT05539677

AAAA-A18-118032890188-9

Details and patient eligibility

About

The investigators will collect biosamples of patient blood and tumour tissue for further immunological analysis of blood cell subpopulations, immunosupressive factors concentration, HLA expression an lymphocytes and tumour tissue, and and cancer testis antigenes expression on tumour cells, as well as clinical data on patient's stage, therapy, response and demographics. Possible prognostic and predictive dynamic biomarkers will be discovered for individualisation of treatment strategies

Enrollment: 1,000 estimated patients

Sex: All

Ages: 1+ year old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Signed inform consent
• Histolgically verified solid tumour
• Receiving systemic therapy for neoplasm
• Has archival tumour tissue
• Provide biosamples with living tumour tissue or blood samples for immunologic assessment

Exclusion criteria

• Concurrent Lymphoprolipherative disorder
• Patients after stem cell or bone marrow thansplantation
• Incomplete informaton on previous cancer history or medical history
• Patients with known primary immunodeficiency
• Patients receiving immunosupressive therapy for concurrent illness
• Pregnant patients

Trial design

1,000 participants in 7 patient groups

Melanoma

Soft tissue sarcoma

Kidney cancer

Primary brain tumors

Malignant neoplasms

Prostate cancer

Colorectal cancer