Biobank for "Arrhythmia and Conduction Disorders: TowArd Pathophysiology Based Treatment" (ADAPT)

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Status: Enrolling

Conditions: Arrythmia; Pathophysiology; Conduction Disorder

Treatments: Other: Biobank for One or more of following fat patches: epicardial fat, subcutaneous fat, pericardial fat, visceral fat.; Other: Biobank for Blood; Other: Biobank for Left atrial appendage tissue

Study type: Observational

Funder types: Other

Identifiers

NCT04776642

2014_054#A201436

Details and patient eligibility

About

The 'ADAPT' Biobank is a collection of body material and data from patients with or at risk of cardiac arrhythmias who underwent or will undergo (non-) invasive treatment for this disease. Its main objective is to obtain a comprehensive collection of patient information and material to facilitate research and gain better insight into the complex pathophysiology of the different arrhythmias, the multifactorial process, the heterogeneity in clinical presentation, and prognosis.

Bodily material is used for biochemical marker assessments, histological and molecular analyses for research in cardiac arrhythmias.

Full description

The pathophysiological process of many cardiac arrhythmias is complex because of its multifactorial character. Despite extensive research that has already been performed in the field of electrophysiology the exact pathophysiological process of the different arrhythmias remains incompletely understood. The ability to identify subgroups of patients within a population with the same type of arrhythmia that can benefit from a specific treatment strategy might provide more individualized therapeutic opportunities, improve prognostication or provide preventive opportunities in patient with cardiac arrhythmias. Biobanks can make a valuable contribution to the development of diagnostic, preventive and therapeutic methods. More insights into the correlations between genes, environmental factors and susceptibility to illness may be of great value. The 'ADAPT' Biobank has been designed to establish a systematic and qualitative collection of bodily materials for future research in the cardiovascular field. The Biobank includes bodily material of patients with cardiac arrhythmias undergoing (non-) invasive treatment or control patients undergoing cardiothoracic surgery. Clinical data related to the cardiac arrhythmic disease is recorded. The data and samples will be linked to the participants' medical records to allow longitudinal follow-up.

Enrollment: 1,000 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion criteria:

• Patients visiting the AMC outpatient clinic

• Patients included in an ongoing clinical trial linked to this biobank. Studies are listed under point "Groups and interventions" and include:

  • MARK AF
  • INDICO AF
  • PREDICT AF
  • WEIGHTLOSS AF
  • MAD AF

• Patients included in future clinical trial linked to this biobank. Studies may be linked to this biobank that investigates prevalent or incident cardiac arrhythmias.

• Cardiac arrhtymias are defined as

  • Supraventricular tachycardia, among which the most common are:

    • Atrial Fibrillation (AF)
    • Atrial Tachycardia (AT)
    • Atrial Flutter (AFL)
    • Atrioventricular Nodal Reentrant Tachycardia (AVNRT)
    • Atrioventricular Reentrant Tachycardia (AVRT)

  • Ventricular tachycardia, among which the most common are:

    • Ventricular Tachycardia (VT)
    • Ventricular Flutter (VFL)
    • Ventricular Fibrillation (VF)

  • Bradycardia:

    • Sinus Node Dysfunction
    • AV Node Dysfunction
    • Interventricular Conduction Disorder

  • Arrhythmogenic cardiomyopathies, among which the most common are:

    • Dilated Cardiomyopathy
    • Restrictive Cardiomyopathy
    • Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)

Exclusion criteria (shared for all studies):

• Age < 18
• Unable or unwilling to comply with study procedures
• Pregnancy or of childbearing potential without adequate contraception
• NYHA class IV heart failure symptoms or left ventricular ejection fraction <35%.

Trial design

1,000 participants in 7 patient groups

MARK_AF

Description:

MARKers of ATrial Remodeling in Patietns with Atrial Fibrillation. Patients with paroxysmal and persistent atrial fibrillation undergoing thoracoscopic atrial fibrillation ablation surgery

Treatment:

Other: Biobank for One or more of following fat patches: epicardial fat, subcutaneous fat, pericardial fat, visceral fat.

Other: Biobank for Left atrial appendage tissue

Other: Biobank for Blood

INDICO AF

Description:

Atrial Fibrillation in Patients With an Implantable Cardioverter Defibrillator and Coronary Artery Disease. Investigate the incidence of new-onset AF in patients with coronairy artery disease and an impaired LVEF, who will receive a single chamber ICD as primary prevention for sudden cardiac death.

Treatment:

Other: Biobank for Blood

PREDICT AF

Description:

PREDICT AF, Tissue, Blood and biomarkers to predict future Atrial Fibrillation. Patients without a history of atrial fibrillation undergoing cardiothoracic surgery

Treatment:

Other: Biobank for One or more of following fat patches: epicardial fat, subcutaneous fat, pericardial fat, visceral fat.

Other: Biobank for Left atrial appendage tissue

Other: Biobank for Blood

WEIGHTLOSS AF

Description:

The change of adipose tissue characteristics upon drastic weight loss: Implications for atrial fibrillation.

Treatment:

Other: Biobank for One or more of following fat patches: epicardial fat, subcutaneous fat, pericardial fat, visceral fat.

Other: Biobank for Blood

MAD AF

Description:

(123I-mIBG And Defibrillation for Atrial Fibrillation) Enhanced sympathetic activity as a mechanism of Atrial Fibrillation. Patients will undergo 123I-mIBG scintigraphy within 7 days before and six week after an elective cardioversion is performed.

Treatment:

Other: Biobank for Blood

Adapt Biobank - AF surgery

Description:

Patients with Atrial Fibrillation who only donate blood and tissue for the biobank. Patients undergo thorascopic surgery, LAA will be amputated, blood will be collected.

Treatment:

Other: Biobank for One or more of following fat patches: epicardial fat, subcutaneous fat, pericardial fat, visceral fat.

Other: Biobank for Left atrial appendage tissue

Other: Biobank for Blood

Adapt Biobank - blood

Description:

Patients with cardiac arrhythmias who only donate blood for the ADAPT biobank.

Treatment:

Other: Biobank for Blood