Biochemical Approach to Measuring Surgical Trauma

Hamilton Health Sciences (HHS)

Status: Withdrawn

Conditions: Total Knee Replacement

Study type: Observational

Funder types: Other

Identifiers

NCT01037400

TKR Study

Details and patient eligibility

About

This study will examine the magnitude and time course of changes in circulating (serum and plasma) biomarker concentrations associated with musculoskeletal injury created by total knee replacement surgery. The sensitivity to injury will be characterized by the changes in mean serum concentration before and after surgery. Specificity for the injured state will be evaluated comparing the baseline to peak change (injury response) with the pre-surgery to follow-up baseline fluctuation (i.e. measurement noise).

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria

• Age 18 to 75
• No musculoskeletal injury requiring medical attention in the past 3 months other than entirely related to worsening symptoms of the operative knee or spinal level.
• No musculoskeletal injury producing pain in the previous 2 weeks.
• No inflammatory disease other than osteoarthritis)
• No exercise with weights in the 2 weeks before surgery.

Trial design

0 participants in 1 patient group

Total Knee Replacement Patients

Description:

Forty men and women ages 18-75 undergoing unilateral (n = 20) or bilateral (n = 20) knee replacement surgery with no musculoskeletal injury requiring medical attention in the past 3 months or producing pain in the previous 2 weeks and no inflammatory disease other than osteoarthritis.