Biochemical Predictors of Delirium in Cardiac Surgery

Meshalkin Research Institute of Pathology of Circulation

Status: Unknown

Conditions: Postoperative Delirium

Treatments: Diagnostic Test: Metabolomic analysis

Study type: Observational

Funder types: Other; NETWORK

Identifiers

NCT03931499

DEL2019

Details and patient eligibility

About

Delirium is a common neurologic complication after cardiac surgery occuring in 30-50% of patients. The occurence of this complication is associated with worse outcomes, including prolonged length of stay in the ICU and hospital, increased morbidity and mortality. Considering great clinical significance of this complication, the search for early predictors of postoperative delirium remains an urgent task. The purpose of this prospective observational study is to test the hypothesis that metabolomic changes before and after cardiac surgery could be served as early predictors of this complication.

Enrollment: 100 estimated patients

Sex: All

Ages: 60 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• surgery under cardiopulmonary bypass
• Age > 60 years
• CABG surgery or valve surgery (repair/replacement)

Exclusion criteria

• urgent surgery
• surgery on aorta
• combined procedures (CABG+valves)
• significant stenosis of carotid arteries
• Parkinson's disease
• liver cirrhosis
• use of anticholinergic drugs, antidepressants, antiepileptic or chemotherapy drugs

Trial design

100 participants in 1 patient group

Study cohort

Description:

Patients undergoing surgery under cardiopulmonary bypass

Treatment:

Diagnostic Test: Metabolomic analysis