Bioidentical Hormone Replacement Therapy in Postmenopausal Women

Gaziosmanpasa Research and Education Hospital

Status: Completed

Conditions: Hormon Replacement Terapy

Study type: Observational

Funder types: Other

Identifiers

NCT07163442

GaziosmanpasatrehmENA

Details and patient eligibility

About

The aim of this observational study is to investigate the effects of bioidentical HRT over a 1-year period in postmenopausal women receiving transdermal estradiol and, when necessary, progesterone. The main question the study aims to answer is:

Does bioidentical hormone replacement therapy, when used long-term in postmenopausal women, reduce the negative effects of menopause compared to women who do not receive it? Participants who were already receiving bioidentical transdermal estradiol and micro-dose progesterone as part of their regular medical care under postmenopausal hormone therapy were compared to a group not receiving such therapy over a one-year period, with measurements taken of bone densitometry, mammography, blood lipid parameters (HDL, LDL, VLDL, total cholesterol), and HbA1c levels.

Full description

The aim of this observational study is to investigate the effects of bioidentical HRT over a 1-year period in postmenopausal women receiving transdermal estradiol and, when necessary, progesterone. The main question the study aims to answer is:

Does bioidentical hormone replacement therapy, when used long-term in postmenopausal women, reduce the negative effects of menopause compared to women who do not receive it? Participants who were already receiving bioidentical transdermal estradiol and micro-dose progesterone as part of their regular medical care under postmenopausal hormone therapy were compared to a group not receiving such therapy over a 1-year period, with measurements taken of bone densitometry, mammography, blood lipid parameters (HDL, LDL, VLDL, total cholesterol), and HbA1c levels. Additionally, they were asked to complete a questionnaire aimed at assessing the severity of vasomotor symptoms during menopause. The patients were divided into two groups. Group 1 consisted of women who had been in menopause for one year and had never taken HRT, while Group 2 consisted of women who had been in menopause for one year or more and were using transdermal bioidentical HRT and micronized progesterone. The values of these two groups were compared to evaluate the effect of HRT

Enrollment: 107 patients

Sex: Female

Ages: 45+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Being in menopause for a year
• being on hormone replacement therapy

Exclusion criteria

• taking HRT in addition to the drugs monitored in the study
• having a hormone-secreting endocrine disorder
• having endocrine cancer(breast cancer...)

Trial design

107 participants in 2 patient groups

grup:1 group not taking postmenopausal hormones

Description:

postmenopausal women who have been in menopause for at least 1 year and have not taken any hormone supplements

grup 2: Patients who have been receiving HRT for 1 year

Description:

Patients who have been using HRT for at least 1 year since the onset of menopause