Biological Age Predicts 90-Day Mortality in Advanced Cancer (BIOAGE-CAN)

Ankara Etlik City Hospital

Status: Completed

Conditions: Advanced Solid Tumors Cancer; Hospitalizations

Treatments: Other: PhenoAge-Based Biological Age Assessment

Study type: Observational

Funder types: Other

Identifiers

NCT07035470

AEŞH-BADEK-2025-0149

Details and patient eligibility

About

This retrospective study evaluates whether biological age, calculated using the PhenoAge model, predicts short-term outcomes in patients with advanced cancer who were hospitalized. The main goal is to investigate associations between biological age and short-term mortality, functional status (ECOG), comorbidity burden (mCCI), and length of hospital stay. All data were collected from medical records without any patient intervention.

Full description

This is a retrospective observational study including hospitalized adult patients with stage III or IV solid tumors admitted to Etlik City Hospital between November 5, 2022 and December 31, 2024. Patients were included if they stayed for ≥48 hours and had all required laboratory values for calculating biological age using the Levine PhenoAge model. The study aimed to evaluate the association between biological age and (1) 30- and 90-day mortality, (2) ECOG performance score, (3) modified Charlson Comorbidity Index (mCCI), and (4) hospital length of stay. Regression and survival analyses were used to identify prognostic factors. All data were anonymized and collected retrospectively from hospital records.

Enrollment: 1,615 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Hospitalized in the Medical Oncology Department between November 5, 2022, and December 31, 2024

Histologically confirmed advanced-stage (stage III-IV) solid tumors

Age ≥18 years

Hospital stay of at least 48 hours

Actively receiving chemotherapy or received it within the last 6 months

Availability of all 9 required laboratory tests (albumin, creatinine, glucose, CRP, lymphocyte %, MCV, RDW, ALP, WBC) for PhenoAge calculation during the first admission

Patients with multiple hospitalizations who meet the inclusion criteria will be included

Exclusion criteria

• Elective hospitalizations (e.g., planned chemotherapy, biopsy)

Patients who died during the first admission

Missing required laboratory parameters

ICU patients and unconscious patients

Trial design

1,615 participants in 1 patient group

Hospitalized Advanced Cancer Patients

Description:

Patients hospitalized with advanced solid tumors (Stage III or IV) in the oncology clinic were retrospectively analyzed. Biological age was calculated using the PhenoAge model. Clinical outcomes such as mortality, ECOG score, mCCI, and length of stay were assessed.

Treatment:

Other: PhenoAge-Based Biological Age Assessment