Biological Changes in the Adipose Tissue Among Pregnant Women With Diabetes

Hadassah Medical Center

Status: Unknown

Conditions: Diabetes; Pregnancy

Treatments: Other: Diabetes

Study type: Observational

Funder types: Other

Identifiers

NCT02383537

0633-14-HMO

Details and patient eligibility

About

The aim of the research is to study the effect of miRNA, fat tissue and insulin resistance on the pathophysiology of diabetes during pregnancy. During the study fat tissue, Umbilical cord blood, placenta tissue and subcutaneous fat will be taken from pregnant diabetic woman over going a C-section. Healthy pregnant women will serve as a control group.

Full description

The aim of the research is to study the effect of miRNA, fat tissue and insulin resistance on the pathophysiology of diabetes during pregnancy. During the study:

1. fat tissue, Umbilical cord blood, placenta tissue and subcutaneous fat will be taken from pregnant diabetic woman over going a C-section.
2. Bloods will be analyzed for insulin, c-peptide, glucose and fat profile
3. Placenta and fat tissue will be analyzed for miRNA and total RNA
4. Clinical and anthropometric measurements will be taken from the mother
5. Placenta status will be taken

Enrollment: 150 estimated patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age 18-45
• pregnant
• signed consent form
• going through an elective C-section
• Diabetic
• reference group: healthy women with no background illness

Exclusion criteria

• <18 or >45
• chronic illness that may effect the outcome
• polypharmacy

Trial design

150 participants in 2 patient groups

Pregnant women with diabetes

Description:

Pregnant women with diabetes type 1, type 2 or gestational diabetes

Treatment:

Other: Diabetes

Healthy pregnant women

Description:

Healthy pregnant women with no underlying illness