Biological Determinants of Sputum Rheology in Chronic Airway Diseases (CADRhé)

University Hospital Center (CHU)

Status: Completed

Conditions: Bronchiectasis; Asthma; COPD

Study type: Observational

Funder types: Other

Identifiers

NCT04081740

RECHMPL19_0430

Details and patient eligibility

About

The primary objective of this study is to investigate the biological determinants of sputum rheology variations.

Full description

Secondarily, this study aims to compare rheology parameters between different chronic airway disease sub-populations.

Enrollment: 48 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Affiliate with or beneficiary of the French national single-payer health insurance system
• Patient capable of spontaneous mucus expectoration
• Consulting or hospitalized at the study centre

Inclusion Criteria for the Asthma Group

• Never- or former-smoker (<10 pack-years)
• Medical history compatible with asthma
• Reversible post-brochodilator (or post-corticosteroid test) ventilatory obstruction (ratio of forced expiratory volume in 1 second : forced vital capacity < 70%) or significant variation in respiratory function -- OR -- Bronchial hyperresponsiveness demonstrated during a broncho-provocation test

Inclusion Criteria for the COPD Group

• Current- or former-smokers (>10 pack years)
• Chronic obstructive pulmonary disease according to GOLD criteria

Inclusion Criteria for the Bronchiectasis Group

• Presence of bronchiectasis on computed tomography scan
• Cystic fibrosis has been ruled out

Exclusion criteria

• Patient expresses opposition to the protocol
• Breast feeding or pregnant
• Metastatic neoplastic disease
• Other active pulmonary disease (tuberculosis, interstitial lung disease)
• Recent psychiatric disorder (in the past year and documented via a specialist consult)
• Consumption of illicit drugs or alcoholism
• Patients in an exclusion period determined by another study
• Patients under any type of legal guardianship
• Prisoners
• Impossible to correctly inform the patient
• Does not fluently read French
• Emergency situations

Trial design

48 participants in 3 patient groups

Asthma

Description:

The patients included in this group will have asthma, as specified in the inclusion criteria.

COPD

Description:

The patients included in this group will have COPD, as specified in the inclusion criteria.

Bronchiectasis

Description:

The patients included in this group will have bronchiectasis, as specified in the inclusion criteria.