Biological Evolution of Whipple's Disease (WHIP)

Regional University Hospital Center (CHRU)

Status: Completed

Conditions: Whipple Disease

Study type: Observational

Funder types: Other

Identifiers

NCT06776484

29BRC24.0315 - WHIP

Details and patient eligibility

About

Whipple's disease (WD), a rare systemic infection by Tropheryma whipplei, lacks research on biological abnormalities pre- and post-treatment. This study explores these abnormalities for their diagnostic and monitoring value.

Full description

Whipple's disease (WD) is a rare systemic infection caused by *Tropheryma whipplei*. Despite advancements in diagnosis through PCR and biopsy, there is limited research comparing biological abnormalities before and after treatment. This study aimed to characterize these abnormalities and evaluate their potential for aiding in diagnosis and monitoring.

Enrollment: 20 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with at least one positive PCR test for Whipple's disease and a retained diagnosis at Brest University Hospital between 2010 and 2024
• Major patient

Exclusion criteria

• Minors
• No screening test for Whipple's disease
• Opposition to participation
• Protected patients