Biomagnetic Signals of Intestinal Ischemia II (SQUID)

Vanderbilt University Medical Center

Status: Completed

Conditions: Ischemia

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT00179036

R01DK058197 (U.S. NIH Grant/Contract)

060426

Details and patient eligibility

About

The lack of blood flow to the small intestine causes mesenteric ischemia. Using a Superconducting QUantum Interference Device (SQUID) which measures the magnetic field of the small intestine, we are hoping to identify abnormalities without surgical intervention.

Full description

The electrical activity of the small intestine may contain important information that will help us diagnose gastrointestinal diseases. The major impediment to reducing mortality of mesenteric ischemia is the lack of a noninvasive diagnostic test that identifies the syndrome before extensive necrosis occurs. Mesenteric ischemia is caused by the lack of blood flow to the intestine. The Superconducting QUantum Interference Device (SQUID) measures the magnetic field of the intestinal smooth muscle. By comparing normal smooth muscle and that of patients with mesenteric ischemia, the investigators hope to identify abnormal disease states without surgery.

Enrollment: 17 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Normal subjects and those with diagnosed mesenteric ischemia

Exclusion criteria

• Subjects who report a tendency toward claustrophobia

Trial design

17 participants in 2 patient groups

Good blood flow

Description:

Group without any ischemia to the small intestine

Poor blood flow

Description:

Group with partial ischemia to the small intestine