Biomarker-driven Phenotypic Dissection of Amyotrophic Lateral Sclerosis (DRIVEALS)

Istituto Auxologico Italiano

Status: Enrolling

Conditions: Motor Neuron Disease; Amyotrophic Lateral Sclerosis

Study type: Observational

Funder types: Other

Identifiers

NCT06318598

23M202

Details and patient eligibility

About

The goal of this observational study is to understand the clinical variability in a population of ALS patients using multidimensional biomarkers. The main questions it aims to answer are:

• Which set of biomarkers explain genotypic-phenotypic correlations in ALS?
• Which set of biomarkers can be used to subdivide the ALS population in homogeneous subgroups?

Participants will undergo:

• neurological evaluation
• neurophysiological evaluation
• neuropsychological evaluation
• whole exome sequencing
• biomarker measurement in CSF and plasma

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• diagnosis of ALS or other motor neuron disease
• residence near the study centers

Exclusion criteria

• refusal to participate to the study
• unable/unwilling to perform follow-up visits