Biomarker Expression in Tissue Samples From Patients With Bone Sarcomas

Children's Oncology Group

Status: Completed

Conditions: Recurrent Osteosarcoma; Localized Osteosarcoma; Metastatic Osteosarcoma

Treatments: Other: laboratory biomarker analysis

Study type: Observational

Funder types: NETWORK; NIH

Identifiers

NCT01807052

COG-AOST10B2 (Other Identifier)

AOST10B2

NCI-2013-00112 (Registry Identifier)

Details and patient eligibility

About

This trial studies biomarker expression in tissue samples from patients with bone sarcomas. Studying biomarker in tissue samples from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer

Full description

STUDY SUBTYPE: Ancillary/Correlative

OBSERVATIONAL STUDY MODEL: Case-only

TIME PERSPECTIVE: Retrospective

BIOSPECIMEN RETENTION: Samples without DNA

BIOSPECIMEN DESCRIPTION: Tissue samples obtained from Cooperative Human Tissue Network (CHTN)

STUDY POPULATION DESCRIPTION: Patients enrolled on P9754 and AOST0121 clinical trials

SAMPLING METHOD: Non-probability sample

PRIMARY OBJECTIVES:

I. To determine if there is differential expression of tumor factor (TF) among patients with osteosarcoma.

II. To determine if there is an association between overall survival and disease free survival and the extent of TF expression.

III. To determine if TF expression correlates with presence of gross metastatic disease at presentation, and development of subsequent metastases.

OUTLINE:

Tissue samples are analyzed for tumor factor expression levels by immunohistochemistry.

Enrollment: 34 patients

Sex: All

Ages: Under 39 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Tissue samples from patients with osteosarcomas obtained from the CHTN:

  • P9754 clinical trial for patients with non-metastatic osteosarcoma
  • AOST0121 clinical trial for patients with metastatic or recurrent osteosarcoma

Trial design

34 participants in 1 patient group

Observational

Description:

Tissue samples are analyzed for tumor factor expression levels by immunohistochemistry.

Treatment:

Other: laboratory biomarker analysis