Biomarker Identification for Bladder Cancer Patients

The Ohio State University

Status: Terminated

Conditions: Bladder Cancer

Treatments: Procedure: Sample Collection

Study type: Observational

Funder types: Other

Identifiers

NCT02053662

OSU-12158

Details and patient eligibility

About

To develop a simple blood and urine test that we would perform before patients start their treatment to predict the risk that their bladder cancer might come back. To develop this test the investigators plan to analyze blood, urine and cancer tissue from bladder cancer patients and follow them closely during and after treatment. This will include looking for changes in proteins and genes that might play a role in bladder cancer biology. The investigators will then compare the information obtained from the studies of blood, urine and cancer tissue between patients that are cured and those whose cancer comes back. The knowledge about these differences between patients can then potentially be used to develop a blood or urine test to tell us who has a high risk for having bladder cancer come back.

Enrollment: 179 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients ≥18 years old.
• Patients suspected, clinically diagnosed, or histologically diagnosed bladder cancer.
• Patients undergoing cystoscopy without cancer suspicion.
• Ability to give an informed consent.

Exclusion criteria

• Patients receiving concurrent therapy for a second malignancy.
• < 18 years old.
• Inability to give an informed consent.

Trial design

179 participants in 1 patient group

Bladder Cancer Patients

Description:

Patients with muscle invasive bladder cancer. A sample collection of donated cancer and normal adjacent tissues, blood and urine which will be prospectively obtained from patients through the Tissue Procurement Shared Resources (TPSR) and The Ohio State University Comprehensive Cancer Center Biospecimen and Biorepository Resource (BBR) as needed.

Treatment:

Procedure: Sample Collection