Biomarker in Tissue Samples From Patients With Ewing Sarcoma

Children's Oncology Group

Status: Completed

Conditions: Sarcoma

Treatments: Genetic: microarray analysis; Genetic: protein analysis; Other: laboratory biomarker analysis; Other: immunohistochemistry staining method

Study type: Observational

Funder types: NETWORK; NIH

Identifiers

NCT01365949

COG-AEWS11B1 (Other Identifier)

AEWS11B1 (Other Identifier)

NCI-2011-02857 (Registry Identifier)

Details and patient eligibility

About

RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This research trial studies biomarkers in tissue samples from patients with Ewing sarcoma.

Full description

OBJECTIVES:

• To determine the frequency of INI-1 protein loss in Ewing Sarcoma.

OUTLINE: Previously collected tissue samples are analyzed for INI-1 protein loss by IHC and tissue microarray.

Enrollment: 40 estimated patients

Sex: All

Ages: Under 120 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

DISEASE CHARACTERISTICS:

• Diagnosis of Ewing sarcoma
• Prepared tissue microarray with Ewing sarcoma samples available

PATIENT CHARACTERISTICS:

• Not specified

PRIOR CONCURRENT THERAPY:

• Not specified