Biomarker in Tumor Tissue Samples From Patients With Rhabdomyosarcoma

Children's Oncology Group

Status

Completed

Conditions

Sarcoma

Treatments

Other: laboratory biomarker analysis

Genetic: gene expression analysis

Other: immunohistochemistry staining method

Other: mass spectrometry

Study type

Observational

Funder types

NETWORK

NIH

Identifiers

NCT01365962

ARST11B4 (Other Identifier)

NCI-2011-02858 (Registry Identifier)

COG-ARST11B4 (Other Identifier)

Details and patient eligibility

About

RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This research trial studies biomarkers in tumor tissue samples from patients with rhabdomyosarcoma.

Full description

OBJECTIVES:

To determine and quantify the degree of surface insulin-like growth factor I receptor (IGF-IR) expression in rhabdomyosarcoma (RMS) tumor tissue.
To assess the feasibility and validity of a mass spectrometry assay for IGF-IR expression on paraffin-embedded tumor tissue.

OUTLINE: Paraffin-embedded tumor tissue slides are analyzed for insulin-like growth factor I receptor (IGF-1R) expression by mass spectrometry and correlated with the results obtained by IHC assay.

Enrollment

60 estimated patients

Sex

All

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

DISEASE CHARACTERISTICS: