Biomarker Study for Prediction of aGVHD

Shanghai Jiao Tong University School of Medicine

Status: Unknown

Conditions: aGVHD

Study type: Observational

Funder types: Other

Identifiers

NCT03614143

SHTG-001

Details and patient eligibility

About

This is a prospective study in patients receiving allogeneic stem cell transplantation. The blood samples on Day-14, -7, 0 and every 7 days until D100 were collected together with clinical data. In the final analysis, cytokines and biomarkers analysis will be carried out and compared between patients in No aGVHD and grade II-IV aGVHD.

Full description

This is a prospective study, observation study in patients receiving allogeneic stem cell transplantation in 4 BMT centers in Shanghai. The blood samples (on Day-14, -7, 0 and every 7 days until D100) and clinical data will be collected. In the final analysis, a panel of cytokines and biomarkers analysis of serial blood samples will be carried out and compared between patients with no aGVHD and grade II-IV aGVHD.

Enrollment: 250 estimated patients

Sex: All

Ages: 16 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• all patients undergoing allogeneic stem cel transplantation
• with informed consent
• patients survived without aGVHD or relapse and patients with development of grade II-IV aGVHD

Exclusion criteria

• patients with blood sample and clinical data not available