Biomarker Study in Tissue Samples From Patients With Acute Myeloid Leukemia

Children's Oncology Group

Status

Completed

Conditions

Leukemia

Treatments

Other: fluorescence activated cell sorting

Genetic: cytogenetic analysis

Other: HUMARA assay

Other: laboratory biomarker analysis

Study type

Observational

Funder types

NETWORK

NIH

Identifiers

NCT01232842

AAML11B4 (Other Identifier)

NCI-2011-02843 (Registry Identifier)

COG-AAML11B4 (Other Identifier)

Details and patient eligibility

About

RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer.

PURPOSE: This research study is studying biomarkers in tissue samples from patients with acute myeloid leukemia.

Full description

OBJECTIVES:

Determine the frequency of acute myeloid leukemia (AML) that originates in CD33+ precursors or in which uncontrolled growth is restricted to CD33+ precursors.

OUTLINE: Cryopreserved acute myeloid leukemia cell samples are separated from endothelial cell by fluorescent-activated cell sorting (FACS) and analyzed for X-chromosome inactivation patterns by cytogenetic/molecular analysis and/or Humara assay.

Enrollment

20 estimated patients

Sex

Female

Ages

Under 120 years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

DISEASE CHARACTERISTICS: