Biomarkers and Event Patterns of Vascular Disease in Hemodialysis (HEMOcalc)

Medical University of Graz

Status: Active, not recruiting

Conditions: Vascular Disease; CKD-MBD - Chronic Kidney Disease Mineral and Bone Disorder

Study type: Observational

Funder types: Other

Identifiers

NCT07170761

34-322 ex 21/22

Details and patient eligibility

About

Parathyroid hormone (PTH) remains the central biomarker to classify CKD-metabolic bone disease (CKD-MBD) in hemodialysis patients. While PTH-values are known to be associated with adverse outcomes, interventional studies have failed to show a benefit of pharmacological modulation of PTH levels on hard clinical outcomes. To address this gap, the investigators explored alternative markers of bone metabolism, vascular calcification and inflammation in association to prospective event patterns.

Enrollment: 475 patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Stable hemodialysis > 3 months duration

Exclusion criteria

• Pregnancy
• Acute infections with antibiotic treatment