Biomarkers and Risk Factors for Perioperative Neurocognitive Dysfunction in Elderly Patients

Shandong First Medical University

Status: Enrolling

Conditions: Perioperative Neurocognitive Dysfunction

Treatments: Diagnostic Test: Montreal Cognitive Assessment; Diagnostic Test: Self-rating depression scale; Diagnostic Test: Pittsburgh sleep quality index

Study type: Observational

Funder types: Other

Identifiers

NCT06044207

2023-076-01

Details and patient eligibility

About

Basic information and biological samples of patients were collected preoperatively and intraoperatively, and patients were divided into case and control groups by cognitive function assessment postoperatively, and risk factors and biomarkers of perioperative cognitive dysfunction were derived by analyzing and statistically processing basic information and biological samples.

Enrollment: 1,000 estimated patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age more than or equal to 65 years old
• ASA classification Ⅰ~Ⅲ grade

Exclusion criteria

• History of previous Craniocerebral surgery or Craniocerebral trauma
• Inability to successfully complete preoperative psychological function tests
• Those who are severely deaf, speech impaired and otherwise unable to communicate.

Trial design

1,000 participants in 2 patient groups

Patients with perioperative neurocognitive dysfunction

Treatment:

Diagnostic Test: Montreal Cognitive Assessment

Diagnostic Test: Pittsburgh sleep quality index

Diagnostic Test: Self-rating depression scale

Patients without perioperative neurocognitive dysfunction

Treatment:

Diagnostic Test: Montreal Cognitive Assessment

Diagnostic Test: Pittsburgh sleep quality index

Diagnostic Test: Self-rating depression scale