Biomarkers Correlation With Volemia (ENVOL)

B·R·A·H·M·S

Status: Completed

Conditions: Cerebral Hemorrhage; Head Injury; Poly Trauma Patients Without Heart Failure; Non Traumatic Post Surgery; Renal Insufficiency

Treatments: Other: Biomarkers, red blood cells and plasma assessment

Study type: Interventional

Funder types: Industry

Identifiers

NCT01858675

2011-A01310-41

Details and patient eligibility

About

The purpose of this study is to determine whether the Biomarkers (pro adrenomedullin (MR proADM), pro arginin vasopressin (CT proAVP), pro atrial natriuretic peptid (MR proANP), Pro Endothelin) changes at Day 2, Day 5 and Day 7 of ICU admission are correlated with Intravascular volume assessed by Cr 51 on red blood cells (Day 2 and Day 7) and by I 125 on albumine Day 7. The correlation of these Biomarkers are also evaluted with other markers such as erythropoietin and catecholamines. 80 ICU patients are included.

Enrollment: 66 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 20 Cerebral Hemorrhage
• 20 Head Injury
• 20 post surgery non traumatic non neuro
• 20 Polytrauma patients

Exclusion criteria

• Heart failure NYHA III or IV
• Renal insufficiency creatinin clearance < 30 ml/mn
• age < 18 Y
• Pregnancy

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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66 participants in 1 patient group

Biomarkers, total blood volume

Experimental group

Treatment:

Other: Biomarkers, red blood cells and plasma assessment