Biomarkers for Angiogenesis in Renal Cell Carcinoma and Neuro-endocrine Tumours. (BANN)

University Medical Center Groningen (UMCG)

Status: Completed

Conditions: Carcinoma, Renal Cell; Pancreatic Islet Cell Tumors; Carcinoid Tumor; Neuroendocrine Tumors; Carcinoma

Treatments: Other: Blood sampling by vena punction.

Study type: Observational

Funder types: Other

Identifiers

NCT01398306

230520112

Details and patient eligibility

About

The primary objective of this study is to analyse the concentration dopamine and serotonin in thrombocytes of patients with renal cell carcinoma and neuro-endocrine tumours compared to the concentrations of these catecholamines in healthy volunteers. The concentration dopamine and serotonin in thrombocytes with and without medication will also be evaluated.

Full description

• To analyse the concentration catecholamines in thrombocytes of patients with clear cell renal cell carcinoma and low grade neuroendocrine tumours.
• To compare these concentrations with the concentrations catecholamines in thrombocytes of healthy controls.
• To analyse the concentration catecholamines in thrombocytes of patients with clear cell renal cell carcinoma and patients with low grade neuroendocrine tumours with and without medication.

Enrollment: 40 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 18 years old or older.
• Patients with clear cell renal cell carcinoma with metastases or patients with a low-grade neuro-endocrine tumor with metastases.
• Written informed consent

Exclusion criteria

• Use of L-dopa or SSRI.
• Patients with a second primary malignancy.

Trial design

40 participants in 2 patient groups

Group A

Description:

Patients with clear cell renal cell carcinoma with metastases.

Treatment:

Other: Blood sampling by vena punction.

Group B

Description:

Patients with low grade neuro-endocrine tumours with metastases.

Treatment:

Other: Blood sampling by vena punction.