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MATCH is an observation study of HIV-infected adults on effective antiretroviral therapy (ART) and demographically matched uninfected adults to evaluate muscle and aging.
Full description
MATCH is a non-randomized observational longitudinal study. We will recruit HIV infected adults (50 to 65 years old) and demographically matched uninfected control subjects to be followed for 4 years over the course of a 5 year study. The targeted age range of 50-65 is chosen to evaluate aging HIV infected individuals at risk for early frailty in the United States. All subjects will undergo blood draws and physical function assessment, and a subset will undergo a CT scan of muscle and will have a muscle biopsy taken.
A substudy will be performed on a subgroup of HIV-infected and HIV-uninfected men from the main cohort to measure daily physical activity by using an activity tracker.
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Inclusion criteria
Group 1: HIV positive subjects
Group 2: HIV negative subjects Inclusion Criteria for Group 2 subjects
Exclusion criteria
Exclusion Criteria for Group 1 Subjects
Exclusion Criteria for Group 2 subjects
160 participants in 2 patient groups
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Data sourced from clinicaltrials.gov
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