Biomarkers for Pharmacoresponse in Bipolar Disorder - Coagulation

Karolinska Institute

Status: Active, not recruiting

Conditions: Bipolar Disorder

Study type: Observational

Funder types: Other

Identifiers

NCT06581822

2023-04886-02

Details and patient eligibility

About

Previous studies indicate an association between severe psychiatric disorders, such as bipolar disorder, and increased risk of venous thromboembolism. However, to which extent this association is influenced by lithium treatment is currently unknown. In this prospective cohort study, the investigators aim to investigate the effect of bipolar disorder and lithium treatment on coagulation and the counterpart fibrinolysis.

Full description

The investigators will analyse differences in coagulation

• using a case-control design where cases are bipolar patients not yet treated with lithium, and controls are healthy volunteers (Swedish ethical review authority Dnr 2023-05799-02, PI Kristoffer Månsson, KI).
• using a prospective cohort design, following the patients over time.

Enrollment: 68 patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients diagnosed with bipolar disorder but not yet treated with lithium, where there is a decision by the patient and the responsible doctor to start lithium treatment.

Exclusion criteria

• Inability to give informed consent