Biomarkers for Post-COVID Conditions

Zealand University Hospital

Status: Completed

Conditions: COVID-19; Post-acute COVID-19 Syndrome; Biomarkers; SARS-CoV-2

Study type: Observational

Funder types: Other

Identifiers

NCT05196516

SJ-947 (EMN-2021-07028)

Details and patient eligibility

About

The COVID-19 infection affects humans differently. While some recover quickly and fully, others develop serious illnesses and late complications. The term late complications describe symptoms that last for 12 weeks or longer after COVID-19 infection is detected. The aim of the present project is to investigate whether it is possible to identify genetic factors that occur more frequently in people suffering from COVID-19 late complications than in those who do not develop late complications. The investigators aim to develop a genetic profile that identifies individuals at high risk for late complications of COVID-19. Number and nature of late complications will be analysed to identify patterns in the incidence of late complications associated with certain genetic traits. The study is designed as a case-control study and is expected to include 500 subjects between 18 and 65 years of age who at least 12 weeks ago tested positive for COVID-19; 250 who suffer from late complications and 250 who have fully recovered.

Enrollment: 208 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 18 to 65 years
• SARS-CoV-2 infection proven by a PCR test at least 12 weeks prior to inclusion
• Only cases: Referred to the Clinic of post-COVID conditions located in Region Zealand, Denmark

Exclusion criteria

• Need of being on a respirator during infection with SARS-CoV-2
• Only controls: complain about long covid 12 weeks or more after proven infection with SARS-CoV-2

Trial design

208 participants in 2 patient groups

Cases

Description:

Individuals at age 18 to 65 with a SARS-CoV-2 infection proven by a polymerase chain reaction (PCR) test at least 12 weeks prior to inclusion and who have been referred to the clinic of post-COVID conditions.

Controls

Description:

Healthy volunteers at age 18 to 65 with a SARS-CoV-2 infection proven by a PCR test at least 12 weeks prior to inclusion.