Biomarkers for Prognosis of Ambulatory Chronic Heart Failure Patients

University of Parma

Status: Completed

Conditions: Heart Failure

Study type: Observational

Funder types: Other

Identifiers

NCT01113866

CV-1997-2002_A0013-29943

Details and patient eligibility

About

Biomarkers representing distinct biological domains including neurohormonal, inflammatory, metabolic-nutritional, oxidative-nitrosative and myocardial injury, might alone or in combination provide prognostic information on mortality in heart failure patients with preserved or impaired systolic function.

Full description

Upon enrollment in the study, Troponin I (cTn I), BNP, norepinephrine, plasma renin activity, aldosterone, high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), soluble receptor of interleukin 2 (sIL-2R), leptin, prealbumin, free malondialdehyde, 15-F2t-isoprostane and protein-bound nitrotyrosine were measured in stable ambulatory, non diabetic, elderly heart failure patients. Patients were followed up until death or study termination (31st January 2009).

Enrollment: 124 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• symptomatic congestive heart failure lasting at least six months
• reduced exercise tolerance
• impaired or preserved left ventricular ejection fraction
• cardiomegaly

Exclusion criteria

• acute infection
• rheumatoid or other autoimmune diseases
• primary cachectic states (cancer, thyroid disease, severe liver disease)
• severe chronic lung disease
• neuromuscular disorders
• myocardial infarction within the previous 20 weeks
• diabetes mellitus
• chronic renal failure (serum creatinine level > 2.0 mg/dl, >177 micromol/L)

Trial design

124 participants in 1 patient group

heart failure