Biomarkers for the Detection of Heavy Alcohol Use in Patients With and Without Liver Disease

Universitaire Ziekenhuizen KU Leuven

Status: Active, not recruiting

Conditions: Alcohol Abuse; Liver Disease

Treatments: Procedure: Plasma and head hair collection

Study type: Interventional

Funder types: Other

Identifiers

NCT02873663

S53031

Details and patient eligibility

About

The investigators will test the validity of biomarkers for the detection of heavy alcohol use in patients with and without liver disease.

Full description

The investigators will test the validity of biomarkers for the detection of heavy alcohol use in patients with and without liver disease.

The investigators will test the validity of carbohydrate deficient transferrin (CDT)(using capillary zone electrophoresis) in blood and ethyl glucuronide (EtG)(using Liquid Chromatography-MS-MS) in hair in patients with heavy alcohol use, moderate alcohol use and patients who do not drink alcohol.

Enrollment: 140 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• patients who do not drink alcohol, moderate drinkers (between 0 and 60 g a day) and patients who drink 60 or more grams alcohol a day

Exclusion criteria

• refusal for inclusion

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Factorial Assignment

Masking: Single Blind

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140 participants in 2 patient groups

heavy drinkers

Experimental group

Description:

Plasma and head hair collection

Treatment:

Procedure: Plasma and head hair collection

teetotalers

Experimental group

Description:

Plasma and head hair collection

Treatment:

Procedure: Plasma and head hair collection