Biomarkers in Ankylosing Spondylitis

Kirsehir Ahi Evran Universitesi

Status: Enrolling

Conditions: Ankylosing Spondylitis (AS) / Radiographic Axial SpA (r-axSpA)

Study type: Observational

Funder types: Other

Identifiers

NCT07117344

AhiEvranU-FTR-ŞSE-01

Details and patient eligibility

About

In this study, we aimed to compare serum PGRN(progranulin) and TNF-α levels in AS patients with healthy controls and to determine the relationship between TNF-α inhibitor use and PGRN levels in AS patients.

Full description

Axial Spondyloarthritis is a heterogeneous group of diseases characterised by inflammatory low back pain, sacroiliitis, asymmetric oligoarthritis, dactylitis, enthesitis and uveitis.

The fact that PGRN acts by binding to TNF-α receptors, the use of TNF-α inhibitors in current treatment in patients with AS and the importance of this pathway in disease pathogenesis suggested that PGRN may be a marker associated with disease activity in these patients. In this study, we aimed to compare serum PGRN and TNF-α levels in patients with AS with healthy control group and to determine the relationship between TNF-α inhibitor use and PGRN levels in patients with AS.

In our study, 80 patients aged 20-65 years who were diagnosed with AS according to ASAS 2009 criteria and followed up in our clinic will be included. Patients with pregnancy or lactation status, acute or chronic infection findings, malignancy, and the presence of concurrent secondary rheumatic diseases other than AS will be excluded. As a healthy control group, 80 people aged 20-65 years without pregnancy or lactation, acute or chronic infection, malignancy and rheumatic disease will be recruited. Age, gender, comorbidities, duration of the disease, and medications used by all patients will be recorded. In addition, BASDAI, BASFI, BASMI, ASQoL, ASDAS-CRP, ESR, CRP levels will be recorded to determine the severity of AS clinically in the patient group. Participants in the patient and control groups will be seen at one time and serum PGRN and TNF levels will be measured by ELISA method.

Enrollment: 160 estimated patients

Sex: All

Ages: 20 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Between the ages of 20-65
• Signing the informed consent form
• Axial spondyloarthropathy diagnosis according to ASAS 2009 criteria

Exclusion criteria

• Pregnancy or lactation
• Having signs of acute or chronic infection
• Presence of malignancy
• Having concurrent secondary rheumatic disease other than Axial Spondyloarthropathy

Trial design

160 participants in 3 patient groups

Patients with ankylosing spondylitis on TNF inhibitors

Description:

Participants will be seen at one time and serum PGRN and TNF levels will be measured from each of them by ELISA method.

patients with ankylosing spondylitis taking non-steroidal anti-inflammatory drugs

Description:

Participants will be seen at one time and serum PGRN and TNF levels will be measured from each of them by ELISA method.

Control

Description:

Participants will be seen at one time and serum PGRN and TNF levels will be measured from each of them by ELISA method.