Biomarkers in Bone Marrow Samples From Patients With Acute Promyelocytic Leukemia

Children's Oncology Group

Status: Completed

Conditions: Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Childhood Acute Promyelocytic Leukemia (M3); Adult Acute Myeloid Leukemia; Adult Acute Promyelocytic Leukemia (M3)

Treatments: Other: laboratory biomarker analysis

Study type: Observational

Funder types: NETWORK; NIH

Identifiers

NCT01146223

NCI-2012-02717 (Registry Identifier)

AAML10B7

CDR0000671471 (Other Identifier)

Details and patient eligibility

About

This research study is studying biomarkers in patients with acute promyelocytic leukemia. Studying samples of bone marrow from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and about biomarkers related to cancer.

Full description

OBSERVATIONAL STUDY MODEL: Case-only TIME PERSPECTIVE: Retrospective BIOSPECIMEN RETENTION: Samples With DNA BIOSCPECIMEN DESCRIPTION: Bone marrow STUDY POPULATION DESCRIPTION: Primary Care Clinic SAMPLING METHOD: Non-Probability Sample

PRIMARY OBJECTIVES:

I. To measure WT1 and VEGF-1 expression in patients with acute promyelocytic leukemia.

OUTLINE: This is a multicenter study.

Patient mRNA samples from diagnosis are analyzed via quantitative PCR to measure WT1 and VEGF-1 expression.

Enrollment: 10 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Diagnosis of acute promyelocytic leukemia [t(15;17) translocation]
• Not specified
• Not specified

Trial design

10 participants in 1 patient group

Basic science (correlative studies)

Description:

Patient mRNA samples from diagnosis are analyzed via quantitative PCR to measure WT1 and VEGF-1 expression.

Treatment:

Other: laboratory biomarker analysis