Biomarkers in Chronic Arthritis

University Hospital Center (CHU)

Status: Completed

Conditions: Chronic Arthritis

Treatments: Other: Blood sample

Study type: Observational

Funder types: Other

Identifiers

NCT02909998

2008-A01087-48 (Other Identifier)

8359

Details and patient eligibility

About

Use of genotyping for the optimization of treatment with biologics in chronic arthritis by looking for an association between certain alleles and response to treatment.

Full description

Chronic arthritis in children and in adults represent a public health problem in number and difficulty of treatment. 30% of patients are non-responders and / or relapse upon discontinuation of treatment. Some of these treatments are not always well tolerated, sometimes with infectious complications including tuberculosis limiting the use of biological therapies. This study will validate a battery of genetic markers to predict responders biotherapy, determine the prognosis of patients, these treatments are reserved for the most severe forms, and thus improve the care of patients.

Enrollment: 379 patients

Sex: All

Ages: 3+ months old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All patients treated with biotherapy may be included in this study with all information necessary for regular medical consultations (filling specific monitoring by GPs questionnaires), physical therapists visits, occupational therapists, psychologists.. etc

Exclusion criteria

• Patients treated with biological therapy for non rheumatic disease
• Other inflammatory diseases such as Crohn's disease
• Refusal to participate in the collection