Biomarkers in Dyspnea (BIODYSPNEE)

Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil

Status: Completed

Conditions: Healthy Volunteers

Treatments: Other: Induced dyspnea

Study type: Interventional

Funder types: Other

Identifiers

NCT03056547

ADOREPS_5

Details and patient eligibility

About

To explore biological mechanisms in human model of induced dyspnea, in order to remove the source of dyspnoea, to modify cerebral impact and to allow the development of targeted therapies.

Full description

The aim of the study will be to identify a specific biology and immunology associated with dyspnoea. It will open therapeutic possibilities through a better understanding of the mechanisms of dyspnea.

Healthy volunteers will underwent two types of dyspnea. The subjects will be first familiar with both types of dyspnea and dyspnea measurement scales. Different components of dyspnea will be measured.

Blood tests will be performed at different times (before dyspnea, during dyspnea, 60 and 90 min after dyspnea)

Enrollment: 34 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy volunteers

Exclusion criteria

• pregnancy
• ongoing pain
• respiratory disease
• high levels of depression, panic disorder, or other significant mental health problems
• not fluent in french

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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34 participants in 1 patient group

Induced dyspnea

Experimental group

Treatment:

Other: Induced dyspnea