Biomarkers in EV Associated With Marrow Adiposity in Anorexia (VE_BMAT_AN)

Maimónides Biomedical Research Institute of Córdoba

Status: Not yet enrolling

Conditions: Anorexia Nervosa Restricting Type; Anorexia Nervosa (DSM-IV Revised Criteria)

Study type: Observational

Funder types: Other

Identifiers

NCT06712485

FEIOMM24_001 (Other Grant/Funding Number)

Details and patient eligibility

About

The aim of this observational study is to identify biomarkers in extracellular vesicles associated with medullary adiposity occurring in patients with anorexia nervosa. The main question it aims to answer is:

Can this medullary adiposity be associated with the bone deterioration observed in this population?

Participants will be assessed for body composition and a blood sample will be taken by non-invasive techniques.

Enrollment: 30 estimated patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

For AN group:

• Diagnosis of active AN according to DSM-5 criteria
• BMI of less than 17kg/m2
• Present amenorrhoea in the 3 months prior to the start of the study.

For AN-R group:

• Achieved weight gain of more than 85%.
• Normal menstruation in the last 3 months.

For Control group:

• Population of the same age and gender as the AN and AN-R groups.
• If pubertal population, presenting a chronological age of ± 2 years.
• Normal menstruation
• Normal BMI (>18.5 kg/m2)
• No presence of previous dietary transtrons.

Exclusion criteria

• Not receiving oestrogens, contraceptives or glucocorticoids in the 3 months prior to the start of the study.
• Not to suffer from chronic diseases, such as diabetes, pathologies affecting the bone system or thyroid function.
• Do not take calcium or vitamin supplements.

Trial design

30 participants in 3 patient groups

AN

Description:

Patients with Anorexia Nervosa diagnosed according to the DSM-V criteria.

AN-R

Description:

Patients recovered from Anorexia Nervosa

CON

Description:

Healthy subjects of the same age and gender as all other groups