Biomarkers in Idiopathic Juvenile Arthritis
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Treatments
Details and patient eligibility
About
Juvenile idiopathic arthritis (JIA) is the most common form of arthritis in children. The etiology is unknown. Several types of arthritis fall under the JIA heading. Oligoarticular JIA with antinuclear antibodies affects about half of all children. There 's no specific markers. Our purpose is to identify new markers in this pathology. The ProtoArray®Human Protein Microarray allows rapid and efficient detection of protein interaction using a suitable protein or small molecule probe. The investigators hope so detect novel potential autoantigen biomarkers specific in JIA.
Full description
We select 10 patients with inclusion criteria and 10 controls. We analyse their blood sample (5ml). The ProtoArray® Microarray allows to detect novel protein-protein interactions, to rapidly perform serum profiling using a sensitive method to detect potential autoantigen biomarkers. The ProtoArray® Human Protein Microarray is a high-density protein microarray containing thousands of purified human proteins for protein interaction screening.
Enrollment
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Volunteers
Inclusion and exclusion criteria
Inclusion Criteria for experimental group :
- child age from 2 to 16 years
- Oligoarticular JIA with antinuclear antibodies
- with or without uveitis
Exclusion criteria for experimental group :
- immunosuppressive and biological therapy
Inclusion Criteria for control group :
- child age from 2 to 16 years
Trial design
Primary purpose
Allocation
Interventional model
Masking
20 participants in 2 patient groups
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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