Biomarkers in Parkinsonian Syndromes (PROATYP)

Non-profit organization for scientific research in Parkinson's disease and related disorders

Status: Enrolling

Conditions: Multiple System Atrophy; Parkinson Disease; Progressive Supranuclear Palsy; Parkinsonism; Atypical Parkinsonism

Study type: Observational

Funder types: Other

Identifiers

NCT06501469

642

Details and patient eligibility

About

This is a prospective observational study to identify biomarkers in parkinson syndromes. Patients with parkinsonian syndromes at the early stages of disease will be recruited and will be followed up until their established clinical diagnosis or for at least 5 years. In this population, imaging and wet biomarkers as well as clinical data will b systematically collected.

Enrollment: 200 estimated patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

IΙnclusion Criteria:

• Written informed consent, including consent to monitoring
• Patients with Parkinsonism and disease duration < 2 years
• Patients with Parkinsonism and disease duration > 2 years
• Healthy individuals without any neurological disease

Exclusion Criteria:

• Drug-induced parkinsonism (eg, neuroleptics, lithium, valproic acid, metoclopramide).
• Metabolic conditions related parkinsonism (eg, Wilson's disease, hypoparathyroidism).
• Structural lesions on brain magnetic resonance imaging (MRI) that explain the symptoms, such as normal pressure hydrocephalus, moderate to severe chronic vascular encephalopathy, cerebral infarction, neoplasm
• Other serious diseases that indicate a life expectancy of <5 years.
• Active participation in other interventional clinical studies