Biomarkers In Retinitis Pigmentosa (BIRP)

Johns Hopkins University

Status: Completed

Conditions: Retinitis Pigmentosa

Treatments: Other: Anterior Chamber (AC) tap

Study type: Observational

Funder types: Other

Identifiers

NCT01949623

BIRP

Details and patient eligibility

About

In this study, markers of oxidative stress will be measured in the aqueous humour and plasma of RP patients compared to controls.

Full description

People with Retinitis Pigmentosa have loss of night vision followed by loss of central vision due to damage and death of photoreceptors. One of the mechanisms causing damage is high levels of oxygen in the eye. This damage produces specific biomarkers which can be measured. In this study, these biomarkers will be assessed in people with Retinitis Pigmentosa and compared to controls.

Enrollment: 100 patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Signed informed consent and authorization of use and disclosure of protected health information
• Age more than or equal to 18 years
• For the study group, patients diagnosed with Retinitis Pigmentosa by the investigators
• For the control group, patients undergoing vitreoretinal surgery for macular hole, epiretinal membrane, vitreomacular traction, retinal detachment, neovascular Age-related Macular Degeneration (AMD) and Diabetic Retinopathy will be eligible

Exclusion criteria

• Patients with active or suspected ocular or periocular infection

Trial design

100 participants in 2 patient groups

RP patients

Description:

Retinitis Pigmentosa patients

Treatment:

Other: Anterior Chamber (AC) tap

Controls

Description:

Patients who will be undergoing surgery for macular hole, epiretinal membrane, or vitreomacular traction, patients who have a retinal detachment , patients with neovascular age related macular degeneration and patients with diabetic retinopathy.

Treatment:

Other: Anterior Chamber (AC) tap