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Biomarkers In Retinitis Pigmentosa (BIRP)

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Johns Hopkins University

Status

Completed

Conditions

Retinitis Pigmentosa

Treatments

Other: Anterior Chamber (AC) tap

Study type

Observational

Funder types

Other

Identifiers

Details and patient eligibility

About

In this study, markers of oxidative stress will be measured in the aqueous humour and plasma of RP patients compared to controls.

Full description

People with Retinitis Pigmentosa have loss of night vision followed by loss of central vision due to damage and death of photoreceptors. One of the mechanisms causing damage is high levels of oxygen in the eye. This damage produces specific biomarkers which can be measured. In this study, these biomarkers will be assessed in people with Retinitis Pigmentosa and compared to controls.

Enrollment

100 patients

Sex

All

Ages

18 to 100 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Signed informed consent and authorization of use and disclosure of protected health information
  • Age more than or equal to 18 years
  • For the study group, patients diagnosed with Retinitis Pigmentosa by the investigators
  • For the control group, patients undergoing vitreoretinal surgery for macular hole, epiretinal membrane, vitreomacular traction, retinal detachment, neovascular Age-related Macular Degeneration (AMD) and Diabetic Retinopathy will be eligible

Exclusion criteria

  • Patients with active or suspected ocular or periocular infection

Trial design

100 participants in 2 patient groups

RP patients
Description:
Retinitis Pigmentosa patients
Treatment:
Other: Anterior Chamber (AC) tap
Controls
Description:
Patients who will be undergoing surgery for macular hole, epiretinal membrane, or vitreomacular traction, patients who have a retinal detachment , patients with neovascular age related macular degeneration and patients with diabetic retinopathy.
Treatment:
Other: Anterior Chamber (AC) tap

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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