Biomarkers in Samples From Young Patients With Neuroblastoma

C

Children's Oncology Group

Status

Completed

Conditions

Neuroblastoma

Treatments

Genetic: protein expression analysis
Genetic: western blotting
Other: flow cytometry
Genetic: polymerase chain reaction
Other: laboratory biomarker analysis
Other: immunohistochemistry staining method

Study type

Observational

Funder types

NETWORK
NIH

Identifiers

NCT01358604
NCI-2011-02855 (Registry Identifier)
COG-ANBL11B2 (Other Identifier)
ANBL11B2 (Other Identifier)

Details and patient eligibility

About

RATIONALE: Studying samples of tissue and bone marrow from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research study studies biomarkers in samples from young patients with neuroblastoma.

Full description

OBJECTIVES: Primary To analyze the expression of ROR1 on the surface of primary neuroblastoma cells. To investigate the therapeutic potential of anti-ROR1 monoclonal antibodies (mAbs), bispecific antibodies, and immunotoxins in in vitro and in vivo models of neuroblastoma. OUTLINE: Archived bone marrow and tumor tissue samples are analyzed for ROR1 expression by flow cytometry, western blotting, qPCR, and IHC.

Enrollment

20 patients

Sex

All

Ages

Under 120 years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

DISEASE CHARACTERISTICS:

Diagnosed with neuroblastoma

  • With or without N-myc amplification
  • Primary tumor samples as frozen tissue in liquid nitrogen or -80 degrees C
  • Bone marrow samples from high-risk patients as peripheral blood mononuclear cells (PBMC) that have been cryopreserved with DMSO as viable cells to be used for flow cytometry or slides of bone marrow that can be used for immunohistochemistry

PATIENT CHARACTERISTICS:

Not specified

PRIOR CONCURRENT THERAPY:

Not specified

Trial contacts and locations

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Data sourced from clinicaltrials.gov

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