Biomarkers in Samples From Young Patients With Soft Tissue Sarcoma

Children's Oncology Group

Status

Completed

Conditions

Sarcoma

Treatments

Genetic: nucleic acid sequencing

Other: laboratory biomarker analysis

Genetic: mutation analysis

Genetic: RNA analysis

Genetic: DNA analysis

Study type

Observational

Funder types

NETWORK

NIH

Identifiers

NCT01342783

NCI-2011-02853 (Registry Identifier)

ARST11B2 (Other Identifier)

COG-ARST11B2 (Other Identifier)

Details and patient eligibility

About

RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer.

PURPOSE: This research trial is studying biomarkers in samples from young patients with soft tissue sarcoma.

Full description

OBJECTIVES:

To identify the key components of driver pathways of primary and secondary soft tissue sarcomas.
To perform the next-generation sequencing on primary versus normal on undifferentiated sarcomas.

OUTLINE: Genomic DNA and RNA samples from undifferentiated sarcoma tumors are analyzed by next-generation sequencing for somatic mutations. Normal matched lymphocytes and tissue are also analyzed.

Enrollment

20 estimated patients

Sex

All

Ages

Under 18 years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

DISEASE CHARACTERISTICS: