Biomarkers in Samples From Younger Patients With Wilms Tumor

Children's Oncology Group

Status: Completed

Conditions: Wilms Tumor and Other Childhood Kidney Tumors

Treatments: Other: laboratory biomarker analysis

Study type: Observational

Funder types: NETWORK; NIH

Identifiers

NCT01493817

AREN12B1

NCI-2012-00093 (Registry Identifier)

Details and patient eligibility

About

This research study is studying biomarkers in tissue samples from younger patients with Wilms tumor. Studying samples of tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer. It may also help doctors predict how patients respond to treatment

Full description

PRIMARY OBJECTIVES:

I. To determine whether recruitment of tumor-associated macrophages is related to clinicopathological factors in Wilms tumor (tumor stage, presence of vascular invasion, tumor progression, and survival).

OUTLINE:

Paraffin-embedded specimens are analyzed for macrophage markers. Results of each sample are then compared with patient's tumor stage, presence of vascular invasion, tumor progression, and survival.

Enrollment: 30 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Wilms tissue microarray samples provided by the Children's Oncology Group

Trial design

30 participants in 1 patient group

Basic science (biomarker analysis)

Description:

Paraffin-embedded specimens are analyzed for macrophage markers. Results of each sample are then compared with patient's tumor stage, presence of vascular invasion, tumor progression, and survival.

Treatment:

Other: laboratory biomarker analysis