Biomarkers in the Endometrial Fluid, Tissue, and Follicular Fluid of Moderate/Severe Endometriosis Patients

Region Stockholm

Status

Not yet enrolling

Conditions

Endometriosis

Treatments

Diagnostic Test: Follicular fluid

Diagnostic Test: Endometrial fluid

Diagnostic Test: Endometrial biopsy

Study type

Observational

Funder types

Other

Identifiers

NCT07182643

2025-03224-01

Details and patient eligibility

About

This study aims to explore biomarkers in the endometrial fluid and tissue of women with moderate to severe endometriosis, with a specific focus on those involved in pre-receptive endometrium and embryo implantation. This research has the potential to uncover diagnostic indicators of impaired pre-receptive endometrium, examine pathophysiological pathways, and identify future targets for therapeutic intervention. Ultimately, the findings may contribute to more personalized fertility treatments, offering new hope for women struggling with endometriosis-related infertility.

Enrollment

90 estimated patients

Sex

Female

Ages

18 to 40 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Age 18-40 years old
Diagnosed with moderate/severe endometriosis by ultrasound or laparoscopy (patient group)
Regular menstrual cycles 28-35 days
Speak English or Swedish and agree to participate in the study

Exclusion criteria

Pregnancy or lactation in the last 3 months
Uterine anomalies
Pelvic inflammatory disease, endometritis, STD
Gynaecological cancers or other malignancies in the patient's history
Smoking (more than 10 cigarettes per day) or alcohol abuse
Immunosuppressing medicines
Major abdominal or pelvic surgery in the last 3 months
A specific genetic disease that is diagnosed before PGT in women undergoing treatment