Biomarkers in the Evaluation of Chronic Lung Disease

Northwell Health

Status: Completed

Conditions: Pulmonary Hypertension; Interstitial Lung Disease; Pulmonary Arterial Hypertension

Treatments: Other: Breath Condensate Collector; Other: Pulmonary Exercise Test; Other: Spirometry; Other: Blood Gas

Study type: Observational

Funder types: Other

Identifiers

NCT00926523

GCRC 0274

Details and patient eligibility

About

We hypothesize that hypoxia-induced pulmonary vascular remodeling is mediated by macrophage migration inhibitory factor (MIF), that remodeling is in fact the reflection of a chronic inflammatory process, and that MIF may be a useful biomarker of the severity and progression of both ILD and PH.

Full description

We hypothesize that hypoxia-induced pulmonary vascular remodeling is mediated by macrophage migration inhibitory factor (MIF), that remodeling is in fact the reflection of a chronic inflammatory process, and that MIF may be a useful biomarker of the severity and progression of both ILD and PH.

To study this hypothesis, we have two specific aims:

1. To evaluate plasma MIF concentration as a marker of severity in ILD and PH and
2. To determine the utility of breathe condensate analysis in the evaluation of ILD and PH. If we are successful in identifying MIF as a biomarker, it may identify MIF as a useful therapeutic target, as we have shown in other inflammatory disorders.

Enrollment: 67 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Subject are at least 18 years of age
• Subject has confirmed Pulmonary Hypertension and Interstitial Lung Disease
• Subject are able to complete study procedures, such as spirometry, and Pulmonary Exercise test.

Exclusion criteria

• Subject are pregnant
• Subject is unable to perform tasks associated with study

Trial design

67 participants in 2 patient groups

Healthy Controls

Description:

Subjects are made up of healthy adults

Treatment:

Other: Blood Gas

Other: Breath Condensate Collector

Other: Pulmonary Exercise Test

Other: Spirometry

Affected

Description:

Subjects have Pulmonary Hypertension

Treatment:

Other: Blood Gas

Other: Breath Condensate Collector

Other: Pulmonary Exercise Test

Other: Spirometry