Biomarkers in Tissue Samples From Young Patients With Liver Cancer

Children's Oncology Group

Status: Completed

Conditions: Stage II Childhood Liver Cancer; Childhood Hepatoblastoma; Stage I Childhood Liver Cancer; Stage III Childhood Liver Cancer; Stage IV Childhood Liver Cancer

Treatments: Other: diagnostic laboratory biomarker analysis; Genetic: microarray analysis; Genetic: RNA analysis; Genetic: nucleic acid sequencing; Genetic: gene expression analysis

Study type: Observational

Funder types: NETWORK; NIH

Identifiers

NCT01336881

CDR0000698720 (Other Identifier)

NCI-2011-02852 (Registry Identifier)

AHEP11B1

COG-AHEP11B1 (Other Identifier)

Details and patient eligibility

About

This research trial is studying biomarkers in tissue samples from young patients with liver cancer. Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

Full description

PRIMARY OBJECTIVES:

I. To identify biomarker signatures associated with hepatoblastoma subtypes (by microRNA array profiling), and their potential correlation with liver developmental stages as well as outcome.

II. To correlate expression array data with copy number array data.

SECONDARY OBJECTIVES:

I. To carry out a focused sequencing interrogation of amplified or deleted genomic regions as well as genes in key cell pathways involved in embryonic development and/or stem cell signaling pathways for which preliminary data suggests involvement in the pathogenesis of hepatoblastoma.

II. To perform whole exome sequencing in a subset of tumors.

OUTLINE: This is a multicenter study.

Archived tumor tissue samples are analyzed for hepatoblastoma and other liver tumor biomarkers by microRNA array profiling and exome sequencing. Results are then compared with patients' clinical data.

Enrollment: 99 estimated patients

Sex: All

Ages: Under 16 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Diagnosis of hepatoblastoma or other liver cancer including the following subtypes:

  • Pure fetal histology
  • Transitional histology
  • Small cell undifferentiated histology

• Participated on the Children's Oncology Group (COG) clinical trials

• Available data and tumor samples

Trial design

99 participants in 1 patient group

Correlative (tissue analysis)

Description:

Archived tumor tissue samples are analyzed for hepatoblastoma and other liver tumor biomarkers by microRNA array profiling and exome sequencing. Results are then compared with patients' clinical data.

Treatment:

Other: diagnostic laboratory biomarker analysis

Genetic: nucleic acid sequencing

Genetic: gene expression analysis

Genetic: RNA analysis

Genetic: microarray analysis