Biomarkers in Tumor Tissue Samples From Younger Patients With Rhabdomyosarcoma

Children's Oncology Group

Status: Completed

Conditions: Alveolar Childhood Rhabdomyosarcoma; Embryonal Childhood Rhabdomyosarcoma; Childhood Rhabdomyosarcoma

Treatments: Other: laboratory biomarker analysis

Study type: Observational

Funder types: NETWORK; NIH

Identifiers

NCT01496573

NCI-2012-00094 (Registry Identifier)

ARST12B4

Details and patient eligibility

About

This research trial studies biomarkers in tumor tissue samples from younger patients with rhabdomyosarcoma. Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer

Full description

PRIMARY OBJECTIVES:

I. To demonstrate CRKL expression at the protein level in rhabdomyosarcoma tumors by tissue microarray (TMA).

OUTLINE:

Archived tumor tissue samples are analyzed for CRKL expression.

Enrollment: 77 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Alveolar rhabdomyosarcoma and embryonal rhabdomyosarcoma specimens from the Children Oncology Group (COG) tumor microarrays (TMAs)

Trial design

77 participants in 1 patient group

Basic science (biomarker analysis)

Description:

Archived tumor tissue samples are analyzed for CRKL expression.

Treatment:

Other: laboratory biomarker analysis