Biomarkers of Acrylamide, Glycidol, POPs, PFAS and Disease Outcomes and OMICs Signatures

Karolinska Institute

Status: Completed

Conditions: Environmental Exposure; Cardiovascular Diseases; Cancer; Disease

Treatments: Other: Biomarkers of acrylamide, glycidol, POPs, PFAS

Study type: Observational

Funder types: Other

Identifiers

NCT05930626

EXP-21-CV8301-OMICS

Details and patient eligibility

About

The aim of the project is to assess the associations between biomarkers of acrylamide and glycidol exposure and disease outcomes in a case-cohort study based on two prospective cohorts with biobanks. The investigators also aim to assess the exposure-affected OMICS signatures and molecular pathways underlying disease development (specifically cardiovascular diseases such as myocardial infarction and stroke and cancer such as breast-, endometrial and colorectal cancer) for these exposures along with persistent organic pollutants (POPs) and per- and polyflouroalkyl substances (PFAS) using a prospective cohort study utilizing and integrating various 'OMICs' technologies.

Enrollment: 9,254 patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 60YO: Men and women of 60 years old residing in Stockholm
• SMC-C: Women residing in Uppsala

Exclusion criteria

• Subjects will be excluded if they had the outcome under investigation at baseline

Trial design

9,254 participants in 2 patient groups

SMC-C

Description:

Swedish Mammography Cohort-clinical (SMC-C) is a clinical sub-cohort established between 2003 and 2008, consisting of 5022 women, 56-80 years of age, living in Uppsala. These women have completed a detailed questionnaire on diet and lifestyle factors and underwent a health examination, dual-energy X-ray absorptiometry and biological sampling.

Treatment:

Other: Biomarkers of acrylamide, glycidol, POPs, PFAS

60YO

Description:

The cohort of 60-years olds (60YO) was established with the aim to study CVD etiology and consists of 4,232 men and women aged 60 years who were randomly selected from Stockholm County and with baseline examination during 1 year in 1997-98. The study participants underwent a health examination, completed a questionnaire, and donated blood samples.

Treatment:

Other: Biomarkers of acrylamide, glycidol, POPs, PFAS