Biomarkers of Aneurysm Wall Strength

Radboud University Medical Center

Status: Unknown

Conditions: Abdominal Aortic Aneurysm

Study type: Observational

Funder types: Other

Identifiers

NCT00740740

Wallstrength_01

Details and patient eligibility

About

The purpose of this study is to identify possible in vivo biochemical and biological markers related to aortic wall strength.

Full description

Rupture of an Abdominal Aortic Aneurysm (AAA) is potentially lethal. prophylactic surgical repair is therefore warranted when the risk of rupture exceeds the risk of complications following surgery. Aneurysm rupture occurs when the forces (stress) acting on the aneurysm wall surpass aneurysm wall strength. Information on both wall stress and strength might therefore improve rupture risk assessment and patient selection for prophylactic repair. Although aneurysm wall stress calculations are possible, no in vivo method exists to determine aneurysm wall strength. This study was designed to identify possible biomarkers of aneurysm wall strength

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient scheduled for transabdominal aortic surgery

Exclusion criteria

• Patient characteristics and aneurysm anatomy suitable for endovascular repair
• Previous aortic surgery

Trial design

50 participants in 3 patient groups

1

Description:

Patients scheduled for elective conventional aneurysm repair

2

Description:

Patients scheduled for emergent conventional aneurysm repair

3

Description:

Patients scheduled for aortic bypass surgery