Biomarkers of Atrial Fibrillation Complicated With Stroke Based on Proteomics and Metabolomics

Yue LI

Status: Unknown

Conditions: Atrial Fibrillation; Stroke

Treatments: Diagnostic Test: Metabolomics; Diagnostic Test: Proteomics

Study type: Observational

Funder types: Other

Identifiers

NCT05181787

AF and stroke 1

Details and patient eligibility

About

Thrombus shedding in patients with atrial fibrillation (AF) can lead to cerebral artery embolism. Stroke caused by AF is very dangerous, which not only threatens the life of patients, but also seriously affects the quality of life. This study aims to explore the biomarkers of stroke in patients with AF by integrating proteomics and metabolomics data, and establish the network relationship of stroke in patients with AF, so as to reveal the molecular mechanism of stroke in patients with AF.

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Age 18 years or above
2. Admission with atrial fibrillation or clinic visit for atrial fibrillation
3. Receive routine anticoagulant therapy;
4. Signing the consent form

Exclusion criteria

1. Pregnant women;
2. Lactating women;
3. Severe mitral stenosis;
4. Severe impairment of liver function;
5. Severe renal insufficiency;
6. Thyroid dysfunction requiring treatment.

Trial design

200 participants in 2 patient groups

AF

Description:

Patients with AF

Treatment:

Diagnostic Test: Metabolomics

Diagnostic Test: Proteomics

AF and stroke

Description:

Patients with AF complicated with stroke

Treatment:

Diagnostic Test: Metabolomics

Diagnostic Test: Proteomics