Biomarkers of Broccoli Intake: A Pilot Study

Beltsville Human Nutrition Research Center (BHNRC)

Status

Completed

Conditions

Healthy Volunteers

Treatments

Other: Broccoli consumption

Study type

Interventional

Funder types

Other U.S. Federal agency

Identifiers

NCT03287115

HS58

Details and patient eligibility

About

The objectives of the study are 1) to characterize plasma and urinary metabolites that originate from glucobrassicin, 1-methoxyglucobrassicin, 4-methoxyglucobrassicin, and 4-hydroxyglucobrassicin, which are the major indole glucosinolates found in broccoli, and 2) to identify novel plasma and urinary metabolites following broccoli consumption that may have roles in reducing the risk of cancer.

Full description

Consumption of Brassica vegetables is inversely associated with incidence of several cancers, including cancer of the lung, stomach, liver, colon, rectum, breast, endometrium, and ovaries. Brassicas are a good source of many nutrients, but the unique characteristic of Brassicas is their rich content of glucosinolates. Breakdown products of indole glucosinolates in Brassica vegetables show promise for reducing the risk of cancer, but have received comparatively less research attention than those of aliphatic glucosinolates. The aim of this study is to investigate plasma and urinary metabolites of indole glucosinolates from broccoli and to identify novel metabolites that may have roles in reducing cancer risk.

Enrollment

6 patients

Sex

All

Ages

21 to 70 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Non tobacco user
Cancer Free
Not currently taking glucosinolate/isothiocyanate containing supplements

Exclusion criteria

Type 2 diabetes requiring the use of diabetes pills, insulin, or non-insulin shots
Use of blood-thinning medications such as Coumadin (warfarin), Dicumarol, or Miradon (anisindione)
History of bariatric surgery or nutrient malabsorption disease (such as celiac disease) or other metabolic disorders requiring special diet recommendations
Pregnant, lactating, or intending to become pregnant during the study period
Crohn's disease or diverticulitis
Suspected or known strictures, fistulas or physiological/mechanical GI obstruction
Self-report of alcohol or substance abuse within the past 12 months and/or current acute treatment or rehabilitation program for these problems (long-term participation in Alcoholics Anonymous is not an exclusion)