Biomarkers of Early Chronic Obstructive Pulmonary Disease (COPD) in Smokers - Longitudinal Study

Lund University

Status: Completed

Conditions: Chronic Obstructive Pulmonary Disease; Lung Cancer; Cardiovascular Disease

Study type: Observational

Funder types: Other

Identifiers

NCT02076061

KOL 001

Details and patient eligibility

About

This is a longitudinal observational study to identify and validate protein biomarkers for COPD (chronic obstructive pulmonary diseases) and cardiovascular disease in smokers and ex-smokers attending primary care. Special emphasize is to correlate biomarkers to different phases of COPD, to progression of the disease, and to treatment of the disease. Furthermore, linkage between COPD, cardiovascular disease, and lung cancer will be investigated by identifying protein biomarkers.

Enrollment: 300 patients

Sex: All

Ages: 35 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Diagnosed with COPD Gold stage 0-IV

Exclusion criteria

Patients with inflammatory diseases Patients with cancer Patients using immune system regulating drugs

Trial design

300 participants in 6 patient groups

GOLD stage I

GOLD Stage II

GOLD Stage III

GOLD Stage IV

Smokers/ex-smokers w/o COPD

non-Smokers w/o COPD