Biomarkers of Inflammation and Endothelial Dysfunction in Patients With Myocardial Infarction With Non-obstructive Coronary Arteries (IMACORN-INFLI)

Hospital Universitario Getafe

Status: Enrolling

Conditions: Inflammation; MINOCA; Endothelial Dysfunction; Biomarkers; Myocardial Infarction

Treatments: Diagnostic Test: Coronariography

Study type: Observational

Funder types: Other

Identifiers

NCT06446895

IMACORN-INFLI

Details and patient eligibility

About

Around 10% of patients with myocardial infarction (MI) present with nonobstructive coronary arteries (MINOCA) which pathophysiology is often uncertain. The aim of the study is to evaluate inflammation and endothelial dysfunction biomarkers in MINOCA patients during both acute and stable phases, comparing them with those with MI and obstructive coronary arteries (MICAD).

Full description

Prospective observational study in patients with Myocardial Infarction (MI) divided into two groups: MI with obstructive coronary arteries (MICAD) and MI with non-obstructive coronary arteries (MINOCA). Levels of interleukin-6, tumor necrosis factor-alpha, high-sensitivity C- reactive protein, and asymmetric dimethylarginine will be determined at three time points: within the 24 hours from the onset of pain, discharge, and two months after MI. The association of biomarkers, normalized by peak troponin value, with the risk of MINOCA will be evaluated using logistic regression.

Enrollment: 400 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients admitted with Myocardial Infarction and undergo a coronariography
• Patients must sign informed consent.

Exclusion criteria

• Patients who don´t sign informed consent

Trial design

400 participants in 2 patient groups

MICAD

Description:

Patients with Myocardial Infarction and Obstructive Coronary Arteries

Treatment:

Diagnostic Test: Coronariography

MINOCA

Description:

Patients with Myocardial Infarction and Non-obstructive Coronary Arteries

Treatment:

Diagnostic Test: Coronariography